pentobarbital will lower the level or result of vinorelbine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unknown.pentobarbital will minimize the extent or influence of midostaurin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Solid CYP3A4 inducers may well lessen midostaurin